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Associations among maternal perfluoroalkyl substance levels, fetal sex-hormone enzymatic gene polymorphisms, and fetal sex hormone levels in the Hokkaido study.

Reproductive toxicology (Elmsford, N.Y.) - 1 Oct 2021

Kobayashi Sumitaka, Sata Fumihiro, Ikeda-Araki Atsuko, Miyashita Chihiro, Itoh Sachiko, Goudarzi Houman, Iwasaki Yusuke, Mitsui Takahiko, Moriya Kimihiko, Shinohara Nobuo, Cho Kazutoshi, Kishi Reiko

Abstract excerpt

Prenatal sex hormones affect fetal growth; for example, prenatal exposure to low levels of androgen accelerates female puberty onset. We assessed the association of perfluoroalkyl substances (PFASs) in maternal sera and infant genotypes of genes encoding enzymes involved in sex steroid hormone biosynthesis on cord sera sex hormone levels in a prospective birth cohort study of healthy pregnant Japanese women...

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PMID: 34536543
DOI: 10.1016/j.reprotox.2021.09.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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