Engineering Circular Aptamer Assemblies with Tunable Selectivity to Cell Membrane Antigens In Vitro and In Vivo

Abstract excerpt

The strategy of enhancing molecular recognition by improving the binding affinity of drug molecules against targets has generated a lot of successful therapeutic applications. However, one critical consequence of such affinity improvement, generally called “on-target, off-tumor” toxicity, emerged as a major obstacle limiting their clinical usage. Herein, we provide a modular assembly strategy that affords...

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