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Article

Genetic variations in immunomodulatory pathways to predict survival in patients with locoregional gastric cancer.

The pharmacogenomics journal - 1 Dec 2017

Sunakawa Y, Cao S, Volz N B, Berger M D, Yang D, Parekh A, Zhang W, Matsusaka S, Ning Y, Stremitzer S, Stintzing S, Sebio A, Okazaki S, Wakatsuki T, Azuma M, Watanabe M, Koizumi W, Wu A H, Lenz H-J

Abstract excerpt

Immunomodulator-targeting therapies are under development in gastric cancer (GC). However, the role of genes modulating anti-tumor immunity in GC remains poorly understood. We investigated the association of variations in genes involved in immunomodulatory pathways with overall survival (OS) in locoregional GC patients. Extracted genomic DNA was analyzed for 35 functional single-nucleotide polymorphisms in genes,...

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Source

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Identifiers

PMID: 27241062
DOI: 10.1038/tpj.2016.46
PMCID: PMC7507965

Genes

IDO1
PDCD1
CTLA4
FOXP3
LAG3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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