Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A pan-cancer analysis revealing the role of TIGIT in tumor microenvironment.

Scientific reports - 18 Nov 2021

Wen Jie, Mao Xueyi, Cheng Quan, Liu Zhixiong, Liu Fangkun

Abstract excerpt

T cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT), an immune checkpoint, plays a pivotal role in immune suppression. However its role in tumor immunity and correlation with the genetic and epigenetic alterations remains unknown. Here, we comprehensively analyzed the expression patterns of the TIGIT and its value of prognostic prediction among 33 types of cancers based on the data collected from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Gene Expression Regulation, Neoplastic
Share to Genome, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kaplan-Meier Estimate

Share to Microsatellite Instability

Share to Proportional Hazards Models

Share to Receptors, Immunologic

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 34795387
DOI: 10.1038/s41598-021-01933-9
PMCID: PMC8602416

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A pan-cancer analysis revealing the role of TIGIT in tumor microenvironment.PMID 34795387Read ↗

Pan-Cancer Analysis of the Associations of TGFBI Expression With Prognosis and Immune CharacteristicsSemantic proximity Read ↗

Pan-cancer analysis of immune checkpoint receptors and ligands in various cells in the tumor immune microenvironmentSemantic proximity Read ↗

A pan-cancer analysis of the oncogenic and immunological roles of transglutaminase 1 (TGM1) in human cancerSemantic proximity Read ↗

A Multi-Omics Analysis of an Exhausted T Cells’ Molecular Signature in Pan-CancerSemantic proximity Read ↗

Identifying immune cells-related phenotype to predict immunotherapy and clinical outcome in gastric cancer.Semantic proximity Read ↗

An immune relevant signature for predicting prognoses and immunotherapeutic responses in patients with muscle‐invasive bladder cancer (MIBC)Semantic proximity Read ↗

Predictive Panel for Immunotherapy in Low-Grade Glioma.Semantic proximity Read ↗

A score of DNA damage repair pathway with the predictive ability for chemotherapy and immunotherapy is strongly associated with immune signaling pathway in pan-cancerSemantic proximity Read ↗

Pan-cancer landscape of T-cell exhaustion heterogeneity within the tumor microenvironment revealed a progressive roadmap of hierarchical dysfunction associated with prognosis and therapeutic efficacySemantic proximity Read ↗

The Immune Landscape of CancerSemantic proximity Read ↗

Characterization of Exhausted T Cell Signatures in Pan-Cancer SettingsSemantic proximity Read ↗

The immune-related gene-based prognostic index predicts the prognosis and effect of immune checkpoint inhibitors in hepatocellular carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.