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Article

Forced enhancer-promoter rewiring to alter gene expression in animal models

31 Jan 2023

Abstract excerpt

Transcriptional enhancers can be in physical proximity of their target genes via chromatin looping. The enhancer at the β-globin locus (locus control region [LCR]) contacts the fetal-type ( HBG ) and adult-type ( HBB ) β-globin genes during corresponding developmental stages. We have demonstrated previously that forcing proximity between the LCR and HBG genes in cultured adult-stage erythroid cells can activate...

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Identifiers

PMID: 36852088
DOI: 10.1016/j.omtn.2023.01.016

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