Article
Clonal Hematopoiesis Mutations Are Present in Atherosclerotic Lesions in Peripheral Artery Disease.
International journal of molecular sciences - 16 Feb 2023
Büttner Petra, Böttner Julia, Krohn Knut, Baber Ronny, Platzbecker Uwe, Cross Michael, Desch Steffen, Thiele Holger, Steiner Sabine, Scheinert Dierk, Metzeler Klaus H, Branzan Daniela
Abstract excerpt
Clonal hematopoiesis (CH)-associated mutations increase the risk of atherosclerotic cardiovascular diseases. However, it is unclear whether the mutations detected in circulating blood cells can also be detected in tissues associated with atherosclerosis, where they could affect physiology locally. To address this, the presence of CH mutations in peripheral blood, atherosclerotic lesions and associated tissues was...
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