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S100 family proteins are linked to organoid morphology and EMT in pancreatic cancer

24 Feb 2023

Abstract excerpt

Epithelial-mesenchymal transition (EMT) is a continuum that includes epithelial, partial EMT, and mesenchymal states, each of which is associated with cancer progression, invasive capabilities, and ultimately, metastasis. We used a lineage-traced sporadic model of pancreatic cancer to generate a murine organoid biobank from primary and secondary tumors, including sublines that underwent partial EMT and complete...

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PMID: 36828915
DOI: 10.1038/s41418-023-01126-z

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