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Article

MUC5AC Genetic Variation Is Associated With Tuberculous Meningitis Cerebral Spinal Fluid Cytokine Responses and Mortality.

The Journal of infectious diseases - 11 Aug 2023

Sabo Michelle C, Thuong Nguyen T T, Chang Xuling, Ardiansyah Edwin, Tram Trinh T B, Hai Hoang T, Nghia Ho D T, Bang Nguyen D, Dian Sofiati, Ganiem A Rizal, Shaporifar Shima, Kumar Vinod, Li Zheng, Hibberd Martin, Khor Chiea Chuen, Thwaites Guy E, Heemskerk Dorothee, van Laarhoven Arjan, van Crevel Reinout, Dunstan Sarah J, Shah Javeed A

Abstract excerpt

BACKGROUND: The purpose of this study was to assess if single nucleotide polymorphisms (SNPs) in lung mucins MUC5B and MUC5AC are associated with Mycobacterium tuberculosis outcomes. METHODS: Independent SNPs in MUC5B and MUC5AC (genotyped by Illumina HumanOmniExpress array) were assessed for associations with tumor necrosis factor (TNF) concentrations (measured by immunoassay) in cerebral spinal fluid (CSF) from...

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Identifiers

PMID: 36823694
DOI: 10.1093/infdis/jiad050
PMCID: PMC10420404

Genes

MUC5AC
TNF
MUC5B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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