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Advantages of long- and short-reads sequencing for the hybrid investigation of the Mycobacterium tuberculosis genome

2 Feb 2023

Abstract excerpt

Introduction: (MTB) genome is constituted by the PE/PPE family, a GC-rich repetitive genome region. Although sequencing using short read technology is widely used, it is well recognized its limit in the PE/PPE regions due to the unambiguously mapping process onto the reference genome. The aim of this study was to compare the performances of short-reads (SRS), long-reads (LRS) and hybrid-reads (HYBR) based...

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PMID: 36819039
DOI: 10.3389/fmicb.2023.1104456

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