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Article

Single-center, observational study of AML/MDS-EB with IDH1/2 mutations: genetic profile, immunophenotypes, mutational kinetics and outcomes.

Hematology (Amsterdam, Netherlands) - 1 Dec 2023

Papadopoulou Vasiliki, Schoumans Jacqueline, Basset Valentin, Solly Françoise, Pasquier Jérôme, Blum Sabine, Spertini Olivier

Abstract excerpt

OBJECTIVE: IDH1/2 mutations, intervening in epigenetic procedures, are frequently encountered in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Knowledge of the genetics, immunophenotypes, and mutational kinetics of IDH1/2-mutated AML can contribute to the understanding of AML clonal architecture and inform therapeutics and monitoring. METHODS: We retrospectively analyzed 50 IDH1/2-mutated...

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Identifiers

PMID: 36815747
DOI: 10.1080/16078454.2023.2180704

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