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Article

Characteristics, clinical outcome, and prognostic significance of IDH mutations in AML.

American journal of hematology - 1 Aug 2015

DiNardo Courtney D, Ravandi Farhad, Agresta Sam, Konopleva Marina, Takahashi Koichi, Kadia Tapan, Routbort Mark, Patel Keyur P, Mark Brandt, Pierce Sherry, Garcia-Manero Guillermo, Cortes Jorge, Kantarjian Hagop

Abstract excerpt

The pathophysiology of IDH mutations in tumorigenesis is increasingly described, yet the prognostic significance of IDH1 and IDH2 mutations in AML remains controversial. The primary objective of this study was to define the natural history and prognosis of patients with AML and IDH1 or IDH2 mutations and provide historical survival expectations. A total of 826 patients treated from 2010 to 2014 at a single...

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Source

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Identifiers

PMID: 26016821
DOI: 10.1002/ajh.24072
PMCID: PMC4612499

Genes

IDH2
IDH1
FLT3
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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