Article
Cytological Diagnosis of Classic Myeloproliferative Neoplasms at the Age of Molecular Biology.
Cells - 20 Mar 2023
Combaluzier Sophie, Quessada Julie, Abbou Norman, Arcani Robin, Tichadou Antoine, Gabert Jean, Costello Régis, Loosveld Marie, Venton Geoffroy, Berda-Haddad Yaël
Abstract excerpt
Myeloproliferative neoplasms (MPN) are clonal hematopoietic stem cell-derived disorders characterized by uncontrolled proliferation of differentiated myeloid cells. Two main groups of MPN, BCR::ABL1-positive (Chronic Myeloid Leukemia) and BCR::ABL1-negative (Polycythemia Vera, Essential Thrombocytosis, Primary Myelofibrosis) are distinguished. For many years, cytomorphologic and histologic features were the only...
Topics
- Humans
- Mutation
- Myeloproliferative Disorders
- Polycythemia Vera
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Molecular Biology