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Article

Structure-informed microbial population genetics elucidate selective pressures that shape protein evolution.

Science advances - 22 Feb 2023

Kiefl Evan, Esen Ozcan C, Miller Samuel E, Kroll Kourtney L, Willis Amy D, Rappé Michael S, Pan Tao, Eren A Murat

Abstract excerpt

Comprehensive sampling of natural genetic diversity with metagenomics enables highly resolved insights into the interplay between ecology and evolution. However, resolving adaptive, neutral, or purifying processes of evolution from intrapopulation genomic variation remains a challenge, partly due to the sole reliance on gene sequences to interpret variants. Here, we describe an approach to analyze genetic...

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PMID: 36812328
DOI: 10.1126/sciadv.abq4632

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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