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Article

Computational analyses and prediction of guanylin deleterious SNPs.

Peptides - 1 Jul 2015

Porto William F, Franco Octávio L, Alencar Sérgio A

Abstract excerpt

Human guanylin, coded by the GUCA2A gene, is a member of a peptide family that activates intestinal membrane guanylate cyclase, regulating electrolyte and water transport in intestinal and renal epithelia. Deregulation of guanylin peptide activity has been associated with colon adenocarcinoma, adenoma and intestinal polyps. Besides, it is known that mutations on guanylin receptors could be involved in meconium...

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PMID: 25899674
DOI: 10.1016/j.peptides.2015.04.013

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