Article
Non-conservative substitutions distinguish previously uncharacterized HLA-A molecules.
Tissue antigens - 1 Feb 2001
Hickman H D, Cavett J W, Ellexson-Turner M E, Sparkman J N, Bennett T T, Turner S, Sidebottom D A, Trachtenberg E A, Confer D L, Hildebrand W H
Abstract excerpt
The extent of class I HLA polymorphism is not yet realized, and to provide a glimpse of the HLA-A polymorphism which remains undetected, we have analyzed approximately 3,700 National Marrow Donor Program (NMDP) Donor/Recipient Pair Retrospective Study Samples with HLA-A DNA sequence-based typing (SBT). Seventeen new HLA-A alleles were detected, with a total of 19 nucleotide substitutions distinguishing these new...
Topics
- Alleles
- Amino Acid Substitution
- Antigen Presentation
- Asian People
- Black People
- HLA-A Antigens
- Humans
- Sequence Analysis, DNA
- White People