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Article

When a Synonymous Variant Is Nonsynonymous.

Genes - 19 Aug 2022

Vihinen Mauno

Abstract excerpt

Term synonymous variation is widely used, but frequently in a wrong or misleading meaning and context. Twenty three point eight % of possible nucleotide substitution types in the universal genetic code are for synonymous amino acid changes, but when these variants have a phenotype and functional effect, they are very seldom synonymous. Such variants may manifest changes at DNA, RNA and/or protein levels. Large...

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PMID: 36011397
DOI: 10.3390/genes13081485
PMCID: PMC9408308

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