Pathologic findings at risk-reducing salpingo-oophorectomy: primary results from Gynecologic Oncology Group Trial GOG-0199.

doi:10.1200/JCO.2013.54.1987

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Article

Pathologic findings at risk-reducing salpingo-oophorectomy: primary results from Gynecologic Oncology Group Trial GOG-0199.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Oct 2014

Sherman Mark E, Piedmonte Marion, Mai Phuong L, Ioffe Olga B, Ronnett Brigitte M, Van Le Linda, Ivanov Iouri, Bell Maria C, Blank Stephanie V, DiSilvestro Paul, Hamilton Chad A, Tewari Krishnansu S, Wakeley Katie, Kauff Noah D, Yamada S Diane, Rodriguez Gustavo, Skates Steven J, Alberts David S, Walker Joan L, Minasian Lori, Lu Karen, Greene Mark H

Abstract excerpt

PURPOSE: Risk-reducing salpingo-oophorectomy (RRSO) lowers mortality from ovarian/tubal and breast cancers among BRCA1/2 mutation carriers. Uncertainties persist regarding potential benefits of RRSO among high-risk noncarriers, optimal surgical age, and anatomic origin of clinically occult cancers detected at surgery. To address these topics, we analyzed surgical treatment arm results from Gynecologic Oncology...

Topics

Adult
Biomarkers, Tumor
Breast Neoplasms
CA-125 Antigen
Fallopian Tube Neoplasms
Female
Genes, BRCA1
Genes, BRCA2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Humans

Middle Aged

Mutation

Neoplasm Invasiveness

Neoplasms, Unknown Primary

Ovarian Neoplasms

Ovariectomy

Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 25199754
DOI: 10.1200/JCO.2013.54.1987
PMCID: PMC4178524

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Pathologic findings at risk-reducing salpingo-oophorectomy: primary results from Gynecologic Oncology Group Trial GOG-0199.PMID 25199754Read ↗

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