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Article

Sex hormones in autism: androgens and estrogens differentially and reciprocally regulate RORA, a novel candidate gene for autism.

PloS one - 16 Feb 2011

Sarachana Tewarit, Xu Minyi, Wu Ray-Chang, Hu Valerie W

Abstract excerpt

Autism, a pervasive neurodevelopmental disorder manifested by deficits in social behavior and interpersonal communication, and by stereotyped, repetitive behaviors, is inexplicably biased towards males by a ratio of ∼4∶1, with no clear understanding of whether or how the sex hormones may play a role in autism susceptibility. Here, we show that male and female hormones differentially regulate the expression of a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Enzymologic

Share to Gonadal Steroid Hormones

Share to Nuclear Receptor Subfamily 1, Group F, Member 1

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Source

Open in PubMed Open full text

Identifiers

PMID: 21359227
DOI: 10.1371/journal.pone.0017116
PMCID: PMC3040206

Genes

RORA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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