Atopic Polygenic Risk Score Is Associated with Paradoxical Eczema Developing in Patients with Psoriasis Treated with Biologics

Abstract excerpt

Biologic therapies for psoriasis can cause paradoxical eczema. The role of genetic factors in its pathogenesis is unknown. To identify risk variants, we conducted a GWAS of 3,212 patients with psoriasis, of whom 88 developed paradoxical eczema. Two lead SNPs reached genome-wide significance ( P ≤ 5 × 10 −8 ) for association with paradoxical eczema: rs192705221 (near UNC5B , P = 9.52 × 10 −10 ) and rs72925168...

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