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Article

LOXL1 Polymorphisms: Genetic Biomarkers that Presage Environmental Determinants of Exfoliation Syndrome.

Journal of glaucoma - 1 Jul 2018

Pasquale Louis R, Kang Jae Hee, Fan BaoJian, Levkovitch-Verbin Hani, Wiggs Janey L

Abstract excerpt

An agnostic high throughput search of the genome revealed a robust association between LOXL1 genetic polymorphisms and exfoliation syndrome (XFS), a discovery that likely would not have been possible with candidate or family-based gene search strategies. While questions remain regarding how LOXL1 gene variants contribute to XFS pathogenesis, it is clear that the frequencies of disease-related alleles do not track...

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Source

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Identifiers

PMID: 29965898
DOI: 10.1097/IJG.0000000000000915
PMCID: PMC6032530

Genes

LOXL1

Provenance

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LOXL1 Polymorphisms: Genetic Biomarkers that Presage Environmental Determinants of Exfoliation Syndrome.PMID 29965898Read ↗

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