Genetic background of pancreatitis.

doi:10.1136/pgmj.2006.050591

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Article

Genetic background of pancreatitis.

Postgraduate medical journal - 1 Dec 2006

Hirota Masahiko, Ohmuraya Masaki, Baba Hideo

Abstract excerpt

Trypsin activity is properly suppressed by pancreatic secretory trypsin inhibitor (PSTI), which is also known as serine protease inhibitor Kazal type 1 (SPINK1), thereby preventing damage to pancreatic acinar cells as a first line of defence. However, if trypsin activation exceeds the capacity of PSTI/SPINK1, a subsequent cascade of events leads to the activation of various proteases that damage cells. Five...

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Share to Trypsin Inhibitor, Kazal Pancreatic
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Identifiers

PMID: 17148697
DOI: 10.1136/pgmj.2006.050591
PMCID: PMC2653919

Genes

SPINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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