Article
Impaired Extracellular Proteostasis in Patients with Heart Failure.
Archives of medical research - 1 Apr 2023
Gouveia Marisol, Teixeira Manuel, Schmidt Cristine, Lopes Mário, Trindade Dário, Magalhães Sandra, Henriques Ana Gabriela, Nunes Alexandra, Santos Mário, Vieira Sandra, Ribeiro Fernando
Abstract excerpt
BACKGROUND: Proteostasis impairment and the consequent increase of amyloid burden in the myocardium have been associated with heart failure (HF) development and poor prognosis. A better knowledge of the protein aggregation process in biofluids could assist the development and monitoring of tailored interventions. AIM: To compare the proteostasis status and protein's secondary structures in plasma samples of...
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