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Article

Molecular Phenogroups in Heart Failure: Large-Scale Proteomics in a Population-Based Cohort.

Circulation. Genomic and precision medicine - 1 Aug 2025

Downie Carolina G, Shearer Joseph J, Kuku Kayode O, Bielinski Suzette J, Kizer Jorge R, Psaty Bruce M, Joo Jungnam, Roger Véronique L

Abstract excerpt

BACKGROUND: Heart failure (HF) is a heterogeneous syndrome with high mortality. The need for a new taxonomy of HF is recognized; up to now, such phenomapping efforts have primarily used clinical data. Proteomics offers potential for more precise phenotypic identification and mechanistic insights. However, few phenomapping studies have used this approach, and all have focused on targeted cardiovascular proteomics...

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Identifiers

PMID: 40665907
DOI: 10.1161/CIRCGEN.124.004953
PMCID: PMC12320929

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