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Article

NS5A domain I antagonises PKR to facilitate the assembly of infectious hepatitis C virus particles

16 Feb 2023

Abstract excerpt

Hepatitis C virus NS5A is a multifunctional phosphoprotein comprised of three domains (DI, DII and DIII). DI and DII have been shown to function in genome replication, whereas DIII has a role in virus assembly. We previously demonstrated that DI in genotype 2a (JFH1) also plays a role in virus assembly, exemplified by the P145A mutant which blocked infectious virus production. Here we extend this analysis to...

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PMID: 36795772
DOI: 10.1371/journal.ppat.1010812

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