Article
Regulation of the production of infectious genotype 1a hepatitis C virus by NS5A domain III.
Journal of virology - 1 Jul 2011
Kim Seungtaek, Welsch Christoph, Yi MinKyung, Lemon Stanley M
Abstract excerpt
Although hepatitis C virus (HCV) assembly remains incompletely understood, recent studies with the genotype 2a JFH-1 strain suggest that it is dependent upon the phosphorylation of Ser residues near the C terminus of NS5A, a multifunctional nonstructural protein. Since genotype 1 viruses account for most HCV disease yet differ substantially in sequence from that of JFH-1, we studied the role of NS5A in the...
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