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A role for domain I of the hepatitis C virus NS5A protein in virus assembly

19 Jan 2018

Abstract excerpt

The NS5A protein of hepatitis C virus (HCV) plays roles in both virus genome replication and assembly. NS5A comprises three domains, of these domain I is believed to be involved exclusively in genome replication. In contrast, domains II and III are required for the production of infectious virus particles and are largely dispensable for genome replication. Domain I is highly conserved between HCV and related...

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PMID: 29352312
DOI: 10.1371/journal.ppat.1006834

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