Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HCV core residues critical for infectivity are also involved in core-NS5A complex formation.

PloS one - 1 Jan 2014

Gawlik Katarzyna, Baugh James, Chatterji Udayan, Lim Precious J, Bobardt Michael D, Gallay Philippe A

Abstract excerpt

Hepatitis C virus (HCV) infection is a major cause of liver disease. The molecular machinery of HCV assembly and particle release remains obscure. A better understanding of the assembly events might reveal new potential antiviral strategies. It was suggested that the nonstructural protein 5A (NS5A), an attractive recent drug target, participates in the production of infectious particles as a result of its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Binding Sites

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to Hepacivirus

Share to Protein Binding

Share to Protein Structure, Tertiary

Share to Viral Core Proteins

Share to Viral Nonstructural Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24533158
DOI: 10.1371/journal.pone.0088866
PMCID: PMC3923060

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HCV core residues critical for infectivity are also involved in core-NS5A complex formation.PMID 24533158Read ↗

Identification of basic amino acids at the N-terminal end of the core protein that are crucial for hepatitis C virus infectivity.Semantic proximity Read ↗

A genetic interaction between the core and NS3 proteins of hepatitis C virus is essential for production of infectious virus.Semantic proximity Read ↗

A role for domain I of the hepatitis C virus NS5A protein in virus assemblySemantic proximity Read ↗

Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly.Semantic proximity Read ↗

Interaction of hepatitis C virus nonstructural protein 5A with core protein is critical for the production of infectious virus particles.Semantic proximity Read ↗

The roles of HCV core protein and its binding host factor in virus assembly and releaseSemantic proximity Read ↗

The nonstructural NS5A protein of hepatitis C virus: An expanding, multifunctional role in enhancing hepatitis C virus pathogenesisSemantic proximity Read ↗

The Replacement of 10 Non-Conserved Residues in the Core Protein of JFH-1 Hepatitis C Virus Improves Its Assembly and Secretion.Semantic proximity Read ↗

The acidic domain of the hepatitis C virus NS4A protein is required for viral assembly and envelopment through interactions with the viral E1 glycoprotein.Semantic proximity Read ↗

Alanine scanning of the hepatitis C virus core protein reveals numerous residues essential for production of infectious virus.Semantic proximity Read ↗

Sequence variability of HCV Core region: important predictors of HCV induced pathogenesis and viral production.Semantic proximity Read ↗

NS4B self-interaction through conserved C-terminal elements is required for the establishment of functional hepatitis C virus replication complexes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.