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Article

Identification of HNRNPK as Regulator of Hepatitis C Virus Particle Production

8 Jan 2015

Abstract excerpt

Hepatitis C virus (HCV) is a major cause of chronic liver disease affecting around 130 million people worldwide. While great progress has been made to define the principle steps of the viral life cycle, detailed knowledge how HCV interacts with its host cells is still limited. To overcome this limitation we conducted a comprehensive whole-virus RNA interference-based screen and identified 40 host dependency and...

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PMID: 25569684
DOI: 10.1371/journal.ppat.1004573

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