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Article

Host heterogeneity and epistasis explain punctuated evolution of SARS-CoV-2

15 Feb 2023

Abstract excerpt

Identifying drivers of viral diversity is key to understanding the evolutionary as well as epidemiological dynamics of the COVID-19 pandemic. Using rich viral genomic data sets, we show that periods of steadily rising diversity have been punctuated by sudden, enormous increases followed by similarly abrupt collapses of diversity. We introduce a mechanistic model of saltational evolution with epistasis and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36791146
DOI: 10.1371/journal.pcbi.1010896

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