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Menaquinone biosynthesis potentiates haem toxicity in S taphylococcus aureus

8 Oct 2012

Abstract excerpt

Staphylococcus aureus is a pathogen that infects multiple anatomical sites leading to a diverse array of diseases. Although vertebrates can restrict the growth of invading pathogens by sequestering iron within haem, S. aureus surmounts this challenge by employing high-affinity haem uptake systems. However, the presence of excess haem is highly toxic, necessitating tight regulation of haem levels. To overcome haem...

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PMID: 23043465
DOI: 10.1111/mmi.12063

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