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Article

MicroRNA-133 controls vascular smooth muscle cell phenotypic switch in vitro and vascular remodeling in vivo.

Circulation research - 30 Sept 2011

Torella Daniele, Iaconetti Claudio, Catalucci Daniele, Ellison Georgina M, Leone Angelo, Waring Cheryl D, Bochicchio Angela, Vicinanza Carla, Aquila Iolanda, Curcio Antonio, Condorelli Gianluigi, Indolfi Ciro

Abstract excerpt

RATIONALE: MicroRNA (miR)-1 and -133 play a crucial role in skeletal and cardiac muscle biology and pathophysiology. However, their expression and regulation in vascular cell physiology and disease is currently unknown. OBJECTIVE: The aim of the present study was to evaluate the role, if any, of miR-1 and miR-133 in vascular smooth muscle cell (VSMC) phenotypic switch in vitro and in vivo. METHODS AND RESULTS: We...

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PMID: 21852550
DOI: 10.1161/CIRCRESAHA.111.240150

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