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Article

Neoadjuvant chemotherapy modulates exhaustion of T cells in breast cancer patients.

PloS one - 1 Jan 2023

Rodríguez Ivon Johanna, Bernal-Estévez David A, Llano-León Manuela, Bonilla Carlos Eduardo, Parra-López Carlos Alberto

Abstract excerpt

Breast cancer is the leading cause of cancer deaths in women worldwide. It has been observed that the incidence of breast cancer increases linearly with age after 45, which suggest a link between cancer, aging, and senescence. A growing body of evidence indicates that the immunosuppressive tumor network in breast cancer patients can lead to T-cell exhaustion and senescence. Cytotoxic chemotherapy is a common...

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Identifiers

PMID: 36763585
DOI: 10.1371/journal.pone.0280851
PMCID: PMC9916600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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