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Article

Senescence and Immunotherapy: Redundant Immunomodulatory Pathways Promote Resistance.

Cancer immunology research - 3 Apr 2023

Oesterreich Steffi, Aird Katherine M

Abstract excerpt

Senescent cancer cells alter their microenvironment through secretion of pro-inflammatory cytokines and chemokines called the senescence-associated secretory phenotype (SASP) and upregulation of immunoinhibitory proteins such as CD80 and programmed death-ligand 1. The senescence field is just beginning to explore the role of these changes on antitumor immunity and response to immunotherapy. In this Perspective,...

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Identifiers

PMID: 36826438
DOI: 10.1158/2326-6066.CIR-23-0051
PMCID: PMC11221415

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