Article
Human RSPO1 Mutation Represses Beige Adipocyte Thermogenesis and Contributes to Diet-Induced Adiposity.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Apr 2023
Sun Yingkai, Zhang Juan, Hong Jie, Zhang Zhongyun, Lu Peng, Gao Aibo, Ni Mengshan, Zhang Zhiyin, Yang Huanjie, Shen Juan, Lu Jieli, Xue Wenzhi, Lv Qianqian, Bi Yufang, Zeng Yi Arial, Gu Weiqiong, Ning Guang, Wang Weiqing, Liu Ruixin, Wang Jiqiu
Abstract excerpt
Recent genetic evidence has linked WNT downstream mutations to fat distribution. However, the roles of WNTs in human obesity remain unclear. Here, the authors screen all Wnt-related paracrine factors in 1994 obese cases and 2161 controls using whole-exome sequencing (WES) and identify that 12 obese patients harbor the same mutations in RSPO1 (p.R219W/Q) predisposing to human obesity. RSPO1 is predominantly...
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