Article
Concentration of non-myocyte proteins in arterial media of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
PloS one - 1 Jan 2023
Lee Soo Jung, Kondepudi Akhil, Young Kelly Z, Zhang Xiaojie, Cartee Naw May Pearl, Chen Jijun, Jang Krystal Yujin, Xu Gang, Borjigin Jimo, Wang Michael M
Abstract excerpt
The most common inherited cause of vascular dementia and stroke, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), is caused by mutations in NOTCH3. Post-translationally altered NOTCH3 accumulates in the vascular media of CADASIL arteries in areas of the vessels that exhibit profound cellular degeneration. The identification of molecules that concentrate in the...
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