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Article

A midposition NOTCH3 truncation in inherited cerebral small vessel disease may affect the protein interactome.

The Journal of biological chemistry - 1 Jan 2023

Lee Soo Jung, Zhang Xiaojie, Xu Gang, Borjigin Jimo, Wang Michael M

Abstract excerpt

Mutations in NOTCH3 underlie cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the most common inherited cerebral small vessel disease. Two cleavages of NOTCH3 protein, at Asp80 and Asp121, were previously described in CADASIL pathological samples. Using monoclonal antibodies developed against a NOTCH3 neoepitope, we identified a third cleavage at Asp964 between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36470429
DOI: 10.1016/j.jbc.2022.102772
PMCID: PMC9808000

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A midposition NOTCH3 truncation in inherited cerebral small vessel disease may affect the protein interactome.PMID 36470429Read ↗

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