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Article

CADASIL brain vessels show a HTRA1 loss-of-function profile.

Acta neuropathologica - 1 Jul 2018

Zellner Andreas, Scharrer Eva, Arzberger Thomas, Oka Chio, Domenga-Denier Valérie, Joutel Anne, Lichtenthaler Stefan F, Müller Stephan A, Dichgans Martin, Haffner Christof

Abstract excerpt

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and a phenotypically similar recessive condition (CARASIL) have emerged as important genetic model diseases for studying the molecular pathomechanisms of cerebral small vessel disease (SVD). CADASIL, the most frequent and intensely explored monogenic SVD, is characterized by a severe pathology in the cerebral...

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Source

Identifiers

PMID: 29725820
DOI: 10.1007/s00401-018-1853-8

Genes

HTRA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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