Research on clinical and molecular genetics of hereditary spastic paraplegia 11 patients in China.

Abstract excerpt

The hereditary spastic paraplegia (HSP) is a rare hereditary disease in nervous system due to the damage of corticospinal tract. HSP has various inheritance modes, including autosomal dominant inheritance, autosomal recessive inheritance, X-linked inheritance, and mitochondrial inheritance in some cases. At present, there are at least 80 subtypes of HSP. Hereditary spastic paraplegia type 11 (SPG11) is the most...

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• Adolescent
• Atrophy
• Child
• Child, Preschool
• Intellectual Disability