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Article

Circulating levels and the bioactivity of miR-30b increase during pubertal progression in boys

19 Jan 2023

Abstract excerpt

Background Puberty marks the transition from childhood to adulthood and is initiated by activation of a pulsatile GnRH secretion from the hypothalamus. MKRN3 functions as a pre-pubertal break on the GnRH pulse generator and hypothalamic expression and circulating levels of MKRN3 decrease peri-pubertally. In rodents, microRNA miR-30b seems to directly target hypothalamic MKRN3 expression – and in boys, circulating...

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PMID: 36742409
DOI: 10.3389/fendo.2023.1120115

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