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Article

Changes in Circulating Levels of miR-30b During Minipuberty and Puberty in Girls

2 Sept 2025

Abstract excerpt

CONTEXT: Pubertal timing is tightly controlled by the hypothalamic-pituitary-gonadal (HPG) axis. Makorin RING finger protein 3 (MKRN3) is an inhibitor of the HPG axis and microRNA-30b (miR-30b) is proposed to act as a direct regulator of hypothalamic MKRN3 expression. Similarly, miR-155 targets CEBPB, which is also suggested to be involved in the activation of the HPG axis. Changes in circulating levels of both...

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PMID: 40899010
DOI: 10.1210/clinem/dgaf489

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