Circulating MKRN3 levels decline prior to pubertal onset and through puberty: a longitudinal study of healthy girls.

doi:10.1210/jc.2014-4462

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Article

Circulating MKRN3 levels decline prior to pubertal onset and through puberty: a longitudinal study of healthy girls.

The Journal of clinical endocrinology and metabolism - 1 May 2015

Hagen Casper P, Sørensen Kaspar, Mieritz Mikkel G, Johannsen Trine Holm, Almstrup Kristian, Juul Anders

Abstract excerpt

CONTEXT: Puberty is initiated by a complex interaction of suppressing and stimulating factors. Genetic studies of familial central precocious puberty have suggested makorin ring finger protein 3 (MKRN3) as a major inhibitor of GnRH secretion during childhood. Furthermore, genetic variation near MKRN3 (rs12148769) affects age at menarche in healthy girls. OBJECTIVE: The purpose of this study was to evaluate...

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PMID: 25695892
DOI: 10.1210/jc.2014-4462

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MKRN3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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Circulating MKRN3 levels decline prior to pubertal onset and through puberty: a longitudinal study of healthy girls.PMID 25695892Read ↗

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