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Article

Central Precocious Puberty Caused by Mutations in the Imprinted Gene <i>MKRN3</i>

5 Jun 2013

Abstract excerpt

BACKGROUND: The onset of puberty is first detected as an increase in pulsatile secretion of gonadotropin-releasing hormone (GnRH). Early activation of the hypothalamic-pituitary-gonadal axis results in central precocious puberty. The timing of pubertal development is driven in part by genetic factors, but only a few, rare molecular defects associated with central precocious puberty have been identified. METHODS:...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Genetic Syndromes and Imprinting
Share to Hypothalamic control of reproductive hormones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23738509
DOI: 10.1056/nejmoa1302160

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Central Precocious Puberty Caused by Mutations in the Imprinted Gene <i>MKRN3</i>PMID 23738509Read ↗

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