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Article

Functional genomics identify causal variant underlying the protective CTSH locus for Alzheimer's disease.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2023

Li Yu, Xu Min, Xiang Bo-Lin, Li Xiao, Zhang Deng-Feng, Zhao Hui, Bi Rui, Yao Yong-Gang

Abstract excerpt

Alzheimer's disease (AD) is the most prevalent age-related neurodegenerative disease, which has a high heritability of up to 79%. Exploring the genetic basis is essential for understanding the pathogenic mechanisms underlying AD development. Recent genome-wide association studies (GWASs) reported an AD-associated signal in the Cathepsin H (CTSH) gene in European populations. However, the exact functional/causal...

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Identifiers

PMID: 36739351
DOI: 10.1038/s41386-023-01542-2
PMCID: PMC10516988

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