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Article

NRXN1 depletion in the medial prefrontal cortex induces anxiety-like behaviors and abnormal social phenotypes along with impaired neurite outgrowth in rat.

Journal of neurodevelopmental disorders - 3 Feb 2023

Wu Di, Zhu Jiansheng, You Lianghui, Wang Jingyu, Zhang Sufen, Liu Zhonghui, Xu Qu, Yuan Xiaojie, Yang Lei, Wang Wei, Tong Meiling, Hong Qin, Chi Xia

Abstract excerpt

BACKGROUND: Neurodevelopmental disorders (NDDs) are a group of disorders induced by abnormal brain developmental processes. The prefrontal cortex (PFC) plays an essential role in executive function, and its role in NDDs has been reported. NDDs are associated with high-risk gene mutations and share partially overlapping genetic abnormalities. METHODS: Neurexins (NRXNs) are related to autism spectrum disorder (ASD)...

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Identifiers

PMID: 36737720
DOI: 10.1186/s11689-022-09471-9
PMCID: PMC9896742

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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