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Article

Obatoclax Rescues FUS-ALS Phenotypes in iPSC-Derived Neurons by Inducing Autophagy.

Cells - 11 Sept 2023

Castillo Bautista Cristina Marisol, Eismann Kristin, Gentzel Marc, Pelucchi Silvia, Mertens Jerome, Walters Hannah E, Yun Maximina H, Sterneckert Jared

Abstract excerpt

Aging is associated with the disruption of protein homeostasis and causally contributes to multiple diseases, including amyotrophic lateral sclerosis (ALS). One strategy for restoring protein homeostasis and protecting neurons against age-dependent diseases such as ALS is to de-repress autophagy. BECN1 is a master regulator of autophagy; however, is repressed by BCL2 via a BH3 domain-mediated interaction. We used...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37759469
DOI: 10.3390/cells12182247
PMCID: PMC10527391

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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