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Distinct breast cancer phenotypes in BRCA 1/2 carriers based on ER status.

Breast cancer research and treatment - 1 Apr 2023

Rosenberg Shai, Devir Michal, Kaduri Luna, Grinshpun Albert, Miner Vardiella, Hamburger Tamar, Granit Avital, Nissan Aviram, Maymon Ofra, Peretz Tamar

Abstract excerpt

PURPOSE: BRCA1/2 genes are the two main genes associated with hereditary breast cancers (BC). In the present study, we explore clinical and molecular characteristics of BRCA-associated BC in relation to estrogen receptor (ER) status. METHODS: Three BC databases (DB) were evaluated: (i) Hadassah oncogenetics (n = 4826); (ii) METABRIC (n = 1980), and (iii) Nick-Zainal (n = 560). We evaluated age at diagnosis in...

Topics

Humans
Female
Breast Neoplasms
Genes, BRCA1
Estrogens
Phenotype

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36729248
DOI: 10.1007/s10549-022-06851-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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