Article
Estrogen receptor status in BRCA1- and BRCA2-related breast cancer: the influence of age, grade, and histological type.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2004
Foulkes William D, Metcalfe Kelly, Sun Ping, Hanna Wedad M, Lynch Henry T, Ghadirian Parviz, Tung Nadine, Olopade Olufunmilayo I, Weber Barbara L, McLennan Jane, Olivotto Ivo A, Bégin Louis R, Narod Steven A
Abstract excerpt
PURPOSE: BRCA1-related breast cancers are more frequently estrogen receptor (ER) negative than are either BRCA2-related or nonhereditary breast cancers. The relationship between ER status and other clinical features of hereditary breast cancers has not been well studied. EXPERIMENTAL DESIGN: ER status, grade, and histological tumor type were evaluated in 1131 women with invasive breast cancer, ascertained at 10...
Topics
- Adult
- Age Factors
- Age of Onset
- Aged
- Aged, 80 and over
- BRCA1 Protein
- BRCA2 Protein
- Breast Neoplasms
- Female
- Genetic Carrier Screening