Article
A fast and efficient approach for gene-based association studies of ordinal phenotypes.
Statistical applications in genetics and molecular biology - 1 Jan 2023
Li Nanxing, Chen Lili, Zhou Yajing, Wei Qianran
Abstract excerpt
Many human disease conditions need to be measured by ordinal phenotypes, so analysis of ordinal phenotypes is valuable in genome-wide association studies (GWAS). However, existing association methods for dichotomous or quantitative phenotypes are not appropriate to ordinal phenotypes. Therefore, based on an aggregated Cauchy association test, we propose a fast and efficient association method to test the...
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