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Epigenetic Regulation and Risk Factors During the Development of Human Gametes and Early Embryos

27 Mar 2019

Abstract excerpt

Drastic epigenetic reprogramming occurs during human gametogenesis and early embryo development. Advances in low-input and single-cell epigenetic techniques have provided powerful tools to dissect the genome-wide dynamics of different epigenetic molecular layers in these processes. In this review, we focus mainly on the most recent progress in understanding the dynamics of DNA methylation, chromatin...

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PMID: 30917080
DOI: 10.1146/annurev-genom-083118-015143

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