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The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity

26 Jan 2023

Abstract excerpt

Protein acetylation plays a key role in regulating cellular processes and is subject to aberrant control in diverse pathologies. Although histone deacetylase (HDAC) inhibitors are approved drugs for certain cancers, it is not known whether they can be deployed in other therapeutic contexts. We have explored the clinical HDAC inhibitor, zabadinostat/CXD101, and found that it is a stand-alone regulator of the...

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PMID: 36702861
DOI: 10.1038/s42003-023-04485-y

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